Protein Details: KCa1.1 (large conductance calcium-activated potassium channels)
Protein ID
ICDB_Pro_1209
Protein Name
KCa1.1 (large conductance calcium-activated potassium channels)
Gene Name
KCNMA1; KCNMA
Organism
Gallus gallus (Chicken)
Length
1137 amino acids
AlphaFoldDB
AF-Q8AYS8-F1-model_v4.pdb
Function
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems; such as regulation of the contraction of smooth muscle; the tuning of hair cells in the cochlea; regulation of transmitter release; and innate immunity. In smooth muscles; its activation by high level of Ca(2+); caused by ryanodine receptors in the sarcoplasmic reticulum; regulates the membrane potential. In cochlea cells; its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX)
Sequence
PDB Structures
Ligand Binding
Binding Site
398;421;423;913;916;919;921
Disease
Location
DOI ID
10.1098/rspb.1997.0104; 10.1016/s0896-6273(00)80397-9; 10.1076/ceyr.17.3.264.5224; 10.1152/ajpheart.1999.276.6.h1827; 10.1016/s0896-6273(00)80285-8; 10.1126/science.283.5399.215
RefSeq
NP_989555.1